diff --git a/packages/node/src/integrations/tracing/mysql2/index.ts b/packages/node/src/integrations/tracing/mysql2/index.ts
deleted file mode 100644
index f2c4489e2230..000000000000
--- a/packages/node/src/integrations/tracing/mysql2/index.ts
+++ /dev/null
@@ -1,6 +0,0 @@
-import { MySQL2Instrumentation } from './vendored/instrumentation';
-import { generateInstrumentOnce } from '../../../otel/instrument';
-
-const INTEGRATION_NAME = 'Mysql2' as const;
-
-export const instrumentMysql2 = generateInstrumentOnce(INTEGRATION_NAME, () => new MySQL2Instrumentation());
diff --git a/packages/node/src/integrations/tracing/mysql2/vendored/instrumentation.ts b/packages/node/src/integrations/tracing/mysql2/vendored/instrumentation.ts
deleted file mode 100644
index c7c0e7e73746..000000000000
--- a/packages/node/src/integrations/tracing/mysql2/vendored/instrumentation.ts
+++ /dev/null
@@ -1,174 +0,0 @@
-/*
- * Copyright The OpenTelemetry Authors
- * SPDX-License-Identifier: Apache-2.0
- *
- * NOTICE from the Sentry authors:
- * - Vendored from: https://github.com/open-telemetry/opentelemetry-js-contrib/tree/15ef7506553f631ea4181391e0c5725a56f0d082/packages/instrumentation-mysql2
- * - Upstream version: @opentelemetry/instrumentation-mysql2@0.64.0
- * - Types from 'mysql2' inlined as simplified interfaces
- * - Minor TypeScript strictness adjustments for this repository's compiler settings
- * - Refactored to use Sentry's span APIs instead of OpenTelemetry tracing APIs
- */
-
-import type { InstrumentationConfig } from '@opentelemetry/instrumentation';
-import { InstrumentationBase, InstrumentationNodeModuleDefinition, isWrapped } from '@opentelemetry/instrumentation';
-import { DB_STATEMENT, DB_SYSTEM, SENTRY_KIND } from '@sentry/conventions/attributes';
-import type { SpanAttributes } from '@sentry/core';
-import { SDK_VERSION, SEMANTIC_ATTRIBUTE_SENTRY_ORIGIN, SPAN_STATUS_ERROR, startInactiveSpan } from '@sentry/core';
-import { InstrumentationNodeModuleFile } from '../../InstrumentationNodeModuleFile';
-import type { Connection, FormatFunction, Query, QueryError, QueryOptions } from './mysql2-types';
-import { DB_SYSTEM_VALUE_MYSQL } from './semconv';
-import { getConnectionAttributes, getConnectionPrototypeToInstrument, getQueryText, getSpanName, once } from './utils';
-
-const PACKAGE_NAME = '@sentry/instrumentation-mysql2';
-const ORIGIN = 'auto.db.otel.mysql2';
-
-// mysql2 >= 3.20.0 publishes via diagnostics_channel and is instrumented by
-// `subscribeMysql2DiagnosticChannels` instead, so this IITM patcher must not
-// overlap it — otherwise every query would emit two mysql2 spans.
-const supportedVersions = ['>=1.4.2 <3.20.0'];
-
-// The raw imported `mysql2` module exposes the `format` helper used to render
-// parameterized queries. Typed shallowly since it is only read internally.
-type MySQL2Module = { format?: FormatFunction; [key: string]: unknown };
-
-export class MySQL2Instrumentation extends InstrumentationBase<InstrumentationConfig> {
-  public constructor(config: InstrumentationConfig = {}) {
-    super(PACKAGE_NAME, SDK_VERSION, config);
-  }
-
-  protected init(): InstrumentationNodeModuleDefinition[] {
-    let format: FormatFunction | undefined;
-    function setFormatFunction(moduleExports: MySQL2Module): void {
-      if (!format && moduleExports.format) {
-        format = moduleExports.format;
-      }
-    }
-    const patch = (ConnectionPrototype: Connection): void => {
-      if (isWrapped(ConnectionPrototype.query)) {
-        this._unwrap(ConnectionPrototype, 'query');
-      }
-      this._wrap(ConnectionPrototype, 'query', this._patchQuery(format) as any);
-      if (isWrapped(ConnectionPrototype.execute)) {
-        this._unwrap(ConnectionPrototype, 'execute');
-      }
-      this._wrap(ConnectionPrototype, 'execute', this._patchQuery(format) as any);
-    };
-    const unpatch = (ConnectionPrototype: Connection): void => {
-      this._unwrap(ConnectionPrototype, 'query');
-      this._unwrap(ConnectionPrototype, 'execute');
-    };
-    return [
-      new InstrumentationNodeModuleDefinition(
-        'mysql2',
-        supportedVersions,
-        (moduleExports: MySQL2Module) => {
-          setFormatFunction(moduleExports);
-          return moduleExports;
-        },
-        () => {},
-        [
-          new InstrumentationNodeModuleFile(
-            'mysql2/promise.js',
-            supportedVersions,
-            (moduleExports: MySQL2Module) => {
-              setFormatFunction(moduleExports);
-              return moduleExports;
-            },
-            () => {},
-          ),
-          new InstrumentationNodeModuleFile(
-            'mysql2/lib/connection.js',
-            supportedVersions,
-            (moduleExports: any) => {
-              const ConnectionPrototype: Connection = getConnectionPrototypeToInstrument(moduleExports);
-              patch(ConnectionPrototype);
-              return moduleExports;
-            },
-            (moduleExports: any) => {
-              if (moduleExports === undefined) return;
-              const ConnectionPrototype: Connection = getConnectionPrototypeToInstrument(moduleExports);
-              unpatch(ConnectionPrototype);
-            },
-          ),
-        ],
-      ),
-    ];
-  }
-
-  private _patchQuery(format: FormatFunction | undefined) {
-    const thisPlugin = this;
-    return (originalQuery: Function): Function => {
-      return function query(
-        this: Connection,
-        query: string | Query | QueryOptions,
-        _valuesOrCallback?: unknown[] | Function,
-        _callback?: Function,
-      ) {
-        let values;
-        if (Array.isArray(_valuesOrCallback)) {
-          values = _valuesOrCallback;
-        } else if (arguments[2]) {
-          values = [_valuesOrCallback];
-        }
-
-        const attributes: SpanAttributes = {
-          [SENTRY_KIND]: 'client',
-          ...getConnectionAttributes(this.config),
-          // oxlint-disable-next-line typescript/no-deprecated
-          [DB_SYSTEM]: DB_SYSTEM_VALUE_MYSQL,
-          // oxlint-disable-next-line typescript/no-deprecated
-          [DB_STATEMENT]: getQueryText(query, format, values),
-          [SEMANTIC_ATTRIBUTE_SENTRY_ORIGIN]: ORIGIN,
-        };
-
-        const span = startInactiveSpan({
-          name: getSpanName(query),
-          attributes,
-        });
-
-        const endSpan = once((err?: QueryError | null) => {
-          if (err) {
-            span.setStatus({ code: SPAN_STATUS_ERROR, message: err.message });
-          }
-          span.end();
-        });
-
-        if (arguments.length === 1) {
-          if (typeof (query as any).onResult === 'function') {
-            thisPlugin._wrap(query as any, 'onResult', thisPlugin._patchCallbackQuery(endSpan));
-          }
-
-          const streamableQuery: Query = originalQuery.apply(this, arguments);
-
-          streamableQuery
-            .once('error', (err: any) => {
-              endSpan(err);
-            })
-            .once('result', () => {
-              endSpan();
-            });
-
-          return streamableQuery;
-        }
-
-        if (typeof arguments[1] === 'function') {
-          thisPlugin._wrap(arguments, 1, thisPlugin._patchCallbackQuery(endSpan));
-        } else if (typeof arguments[2] === 'function') {
-          thisPlugin._wrap(arguments, 2, thisPlugin._patchCallbackQuery(endSpan));
-        }
-
-        return originalQuery.apply(this, arguments);
-      };
-    };
-  }
-
-  private _patchCallbackQuery(endSpan: (err?: QueryError | null) => void) {
-    return (originalCallback: Function) => {
-      return function (...args: [err: QueryError | null, ...rest: unknown[]]) {
-        endSpan(args[0]);
-        return originalCallback(...args);
-      };
-    };
-  }
-}
diff --git a/packages/node/src/integrations/tracing/mysql2/vendored/mysql2-types.ts b/packages/node/src/integrations/tracing/mysql2/vendored/mysql2-types.ts
deleted file mode 100644
index 5b3f105eb997..000000000000
--- a/packages/node/src/integrations/tracing/mysql2/vendored/mysql2-types.ts
+++ /dev/null
@@ -1,47 +0,0 @@
-/*
- * Simplified type definitions from the 'mysql2' package.
- * Only the members actually used by the instrumentation are included.
- */
-
-export interface Connection {
-  config: ConnectionConfig;
-  query: (...args: any[]) => Query;
-  execute: (...args: any[]) => Query;
-  [key: string]: any;
-}
-
-export interface ConnectionConfig {
-  host?: string;
-  port?: number;
-  database?: string;
-  user?: string;
-  connectionConfig?: ConnectionConfig;
-  [key: string]: any;
-}
-
-export interface Query {
-  sql: string;
-  onResult?: (...args: any[]) => any;
-  once(event: string, callback: (...args: any[]) => void): Query;
-  [key: string]: any;
-}
-
-export interface QueryOptions {
-  sql: string;
-  values?: any | any[] | { [param: string]: any };
-  [key: string]: any;
-}
-
-export interface QueryError extends Error {
-  code?: string;
-  errno?: number;
-  sqlState?: string;
-  sqlMessage?: string;
-  [key: string]: any;
-}
-
-export interface FieldPacket {
-  [key: string]: any;
-}
-
-export type FormatFunction = (sql: string, values?: any[], stringifyObjects?: boolean, timeZone?: string) => string;
diff --git a/packages/node/src/integrations/tracing/mysql2/vendored/semconv.ts b/packages/node/src/integrations/tracing/mysql2/vendored/semconv.ts
deleted file mode 100644
index 2dbf2793b106..000000000000
--- a/packages/node/src/integrations/tracing/mysql2/vendored/semconv.ts
+++ /dev/null
@@ -1,11 +0,0 @@
-/*
- * Copyright The OpenTelemetry Authors
- * SPDX-License-Identifier: Apache-2.0
- *
- * NOTICE from the Sentry authors:
- * - Vendored from: https://github.com/open-telemetry/opentelemetry-js-contrib/tree/15ef7506553f631ea4181391e0c5725a56f0d082/packages/instrumentation-mysql2
- * - Upstream version: @opentelemetry/instrumentation-mysql2@0.64.0
- */
-
-export const ATTR_DB_CONNECTION_STRING = 'db.connection_string' as const;
-export const DB_SYSTEM_VALUE_MYSQL = 'mysql' as const;
diff --git a/packages/node/src/integrations/tracing/mysql2/vendored/utils.ts b/packages/node/src/integrations/tracing/mysql2/vendored/utils.ts
deleted file mode 100644
index 28636a9fee4c..000000000000
--- a/packages/node/src/integrations/tracing/mysql2/vendored/utils.ts
+++ /dev/null
@@ -1,119 +0,0 @@
-/*
- * Copyright The OpenTelemetry Authors
- * SPDX-License-Identifier: Apache-2.0
- *
- * NOTICE from the Sentry authors:
- * - Vendored from: https://github.com/open-telemetry/opentelemetry-js-contrib/tree/15ef7506553f631ea4181391e0c5725a56f0d082/packages/instrumentation-mysql2
- * - Upstream version: @opentelemetry/instrumentation-mysql2@0.64.0
- * - Types from 'mysql2' inlined as simplified interfaces
- * - Refactored to use Sentry's span APIs instead of OpenTelemetry tracing APIs
- */
-
-import { DB_NAME, DB_USER, NET_PEER_NAME, NET_PEER_PORT } from '@sentry/conventions/attributes';
-import type { SpanAttributes } from '@sentry/core';
-import type { FormatFunction } from './mysql2-types';
-import { ATTR_DB_CONNECTION_STRING } from './semconv';
-
-interface QueryOptions {
-  sql: string;
-  values?: any | any[] | { [param: string]: any };
-}
-
-interface Query {
-  sql: string;
-}
-
-interface Config {
-  host?: string;
-  port?: number;
-  database?: string;
-  user?: string;
-  connectionConfig?: Config;
-}
-
-export function getConnectionAttributes(config: Config): SpanAttributes {
-  const { host, port, database, user } = getConfig(config);
-
-  const attrs: SpanAttributes = {
-    [ATTR_DB_CONNECTION_STRING]: getJDBCString(host, port, database),
-    // oxlint-disable-next-line typescript/no-deprecated
-    [DB_NAME]: database,
-    [DB_USER]: user,
-    // oxlint-disable-next-line typescript/no-deprecated
-    [NET_PEER_NAME]: host,
-  };
-
-  const portNumber = parseInt(port, 10);
-  if (!isNaN(portNumber)) {
-    // oxlint-disable-next-line typescript/no-deprecated
-    attrs[NET_PEER_PORT] = portNumber;
-  }
-
-  return attrs;
-}
-
-function getConfig(config: any) {
-  const { host, port, database, user } = config?.connectionConfig || config || {};
-  return { host, port, database, user };
-}
-
-function getJDBCString(host: string | undefined, port: number | undefined, database: string | undefined) {
-  let jdbcString = `jdbc:mysql://${host || 'localhost'}`;
-
-  if (typeof port === 'number') {
-    jdbcString += `:${port}`;
-  }
-
-  if (typeof database === 'string') {
-    jdbcString += `/${database}`;
-  }
-
-  return jdbcString;
-}
-
-export function getQueryText(query: string | Query | QueryOptions, format?: FormatFunction, values?: any[]): string {
-  const [querySql, queryValues] =
-    typeof query === 'string' ? [query, values] : [query.sql, hasValues(query) ? values || query.values : values];
-  try {
-    if (format && queryValues) {
-      return format(querySql, queryValues);
-    } else {
-      return querySql;
-    }
-  } catch {
-    return 'Could not determine the query due to an error in formatting';
-  }
-}
-
-function hasValues(obj: Query | QueryOptions): obj is QueryOptions {
-  return 'values' in obj;
-}
-
-export function getSpanName(query: string | Query | QueryOptions): string {
-  const rawQuery = typeof query === 'object' ? query.sql : query;
-  const firstSpace = rawQuery?.indexOf(' ');
-  if (typeof firstSpace === 'number' && firstSpace !== -1) {
-    return rawQuery?.substring(0, firstSpace);
-  }
-  return rawQuery;
-}
-
-export const once = (fn: Function) => {
-  let called = false;
-  return (...args: unknown[]) => {
-    if (called) return;
-    called = true;
-    return fn(...args);
-  };
-};
-
-export function getConnectionPrototypeToInstrument(connection: any) {
-  const connectionPrototype = connection.prototype;
-  const basePrototype = Object.getPrototypeOf(connectionPrototype);
-
-  if (typeof basePrototype?.query === 'function' && typeof basePrototype?.execute === 'function') {
-    return basePrototype;
-  }
-
-  return connectionPrototype;
-}
diff --git a/packages/node/test/integrations/tracing/mysql2.test.ts b/packages/node/test/integrations/tracing/mysql2.test.ts
deleted file mode 100644
index 5d3d2bc42f58..000000000000
--- a/packages/node/test/integrations/tracing/mysql2.test.ts
+++ /dev/null
@@ -1,37 +0,0 @@
-import { describe, expect, it } from 'vitest';
-import { getConnectionPrototypeToInstrument } from '../../../src/integrations/tracing/mysql2/vendored/utils';
-
-// The instrumentation patches `query`/`execute` on whichever prototype actually owns them.
-// mysql2's layout differs across major versions: older versions define them directly on
-// `Connection.prototype`, newer versions inherit them from a base class. This is the only
-// version-sensitive logic in the instrumentation, so it's covered here as a pure unit.
-// The end-to-end span behavior is covered by the real-package integration suite.
-describe('getConnectionPrototypeToInstrument', () => {
-  it('returns the connection prototype when query/execute live on it directly', () => {
-    class Connection {}
-    (Connection.prototype as any).query = (): void => {};
-    (Connection.prototype as any).execute = (): void => {};
-
-    expect(getConnectionPrototypeToInstrument(Connection)).toBe(Connection.prototype);
-  });
-
-  it('returns the base prototype when query/execute are inherited from a base class', () => {
-    class Base {}
-    (Base.prototype as any).query = (): void => {};
-    (Base.prototype as any).execute = (): void => {};
-    class Connection extends Base {}
-
-    expect(getConnectionPrototypeToInstrument(Connection)).toBe(Base.prototype);
-  });
-
-  it('falls back to the connection prototype when the base lacks query/execute', () => {
-    class Base {}
-    (Base.prototype as any).query = (): void => {};
-    // base only has `query`, not `execute` -> not a valid instrumentation target
-    class Connection extends Base {}
-    (Connection.prototype as any).query = (): void => {};
-    (Connection.prototype as any).execute = (): void => {};
-
-    expect(getConnectionPrototypeToInstrument(Connection)).toBe(Connection.prototype);
-  });
-});