diff --git a/mypy/checkpattern.py b/mypy/checkpattern.py
index 9d02262a1530..a27bd23395b1 100644
--- a/mypy/checkpattern.py
+++ b/mypy/checkpattern.py
@@ -358,21 +358,28 @@ def visit_sequence_pattern(self, o: SequencePattern) -> PatternType:
                 new_type = UninhabitedType()
             else:
                 new_type = TupleType(new_inner_types, current_type.partial_fallback)
-
-            num_always_match = sum(is_uninhabited(typ) for typ in rest_inner_types)
-            if num_always_match == len(rest_inner_types):
-                # All subpatterns always match, so we can apply negative narrowing
-                rest_type = UninhabitedType()
-            elif num_always_match == len(rest_inner_types) - 1:
-                # Exactly one subpattern may conditionally match, the rest always match.
-                # We can apply negative narrowing to this one position.
-                rest_type = TupleType(
-                    [
-                        curr if is_uninhabited(rest) else rest
-                        for curr, rest in zip(inner_types, rest_inner_types)
-                    ],
-                    current_type.partial_fallback,
-                )
+                # A value doesn't match the pattern if some item doesn't match its
+                # subpattern while all the items before it do, so what remains is the
+                # union of one tuple per position whose subpattern may fail to match:
+                #     tuple[A, B] - tuple[a, b] == tuple[A - a, B] | tuple[a, B - b]
+                # Positions whose subpattern always matches never fail and keep their type.
+                matched_types = [
+                    curr if is_uninhabited(rest) else new
+                    for curr, new, rest in zip(inner_types, new_inner_types, rest_inner_types)
+                ]
+                rest_items = [
+                    TupleType(
+                        matched_types[:i] + [rest] + inner_types[i + 1 :],
+                        current_type.partial_fallback,
+                    )
+                    for i, rest in enumerate(rest_inner_types)
+                    if not is_uninhabited(rest)
+                ]
+                if rest_items:
+                    rest_type = make_simplified_union(rest_items)
+                else:
+                    # All subpatterns always match, so nothing remains
+                    rest_type = UninhabitedType()
         elif isinstance(current_type, TupleType):
             # For variadic tuples it is too tricky to match individual items like for fixed
             # tuples, so we instead try to narrow the entire type.
diff --git a/test-data/unit/check-python310.test b/test-data/unit/check-python310.test
index 01e490d0da50..3b754efec022 100644
--- a/test-data/unit/check-python310.test
+++ b/test-data/unit/check-python310.test
@@ -2083,10 +2083,95 @@ match m6:
     case (1, "a"):
         reveal_type(m6)  # N: Revealed type is "tuple[Literal[1], Literal['a']]"
     case _:
-        reveal_type(m6)  # N: Revealed type is "tuple[Literal[1] | Literal[2], Literal['a'] | Literal['b']]"
+        reveal_type(m6)  # N: Revealed type is "tuple[Literal[2], Literal['a'] | Literal['b']] | tuple[Literal[1], Literal['b']]"
 
 [builtins fixtures/tuple.pyi]
 
+[case testMatchSequencePatternNegativeNarrowingMultiplePositions]
+# flags: --strict-equality --warn-unreachable
+from typing import Literal, Tuple
+
+m1: Tuple[bool, bool]
+
+match m1:
+    case (True, True):
+        reveal_type(m1)  # N: Revealed type is "tuple[Literal[True], Literal[True]]"
+    case (True, False):
+        reveal_type(m1)  # N: Revealed type is "tuple[Literal[True], Literal[False]]"
+    case (False, True):
+        reveal_type(m1)  # N: Revealed type is "tuple[Literal[False], Literal[True]]"
+    case _:
+        reveal_type(m1)  # N: Revealed type is "tuple[Literal[False], Literal[False]]"
+
+m2: Tuple[bool, int, bool]
+
+match m2:
+    case (True, _, True):
+        reveal_type(m2)  # N: Revealed type is "tuple[Literal[True], builtins.int, Literal[True]]"
+    case _:
+        reveal_type(m2)  # N: Revealed type is "tuple[Literal[False], builtins.int, builtins.bool] | tuple[Literal[True], builtins.int, Literal[False]]"
+
+m3: Tuple[Literal[1], Literal[2]]
+
+match m3:
+    case (1, 3):
+        reveal_type(m3)  # E: Statement is unreachable
+    case _:
+        reveal_type(m3)  # N: Revealed type is "tuple[Literal[1], Literal[2]]"
+
+def f(a: bool, b: bool) -> None:
+    match a, b:
+        case True, True:
+            reveal_type(a)  # N: Revealed type is "Literal[True]"
+            reveal_type(b)  # N: Revealed type is "Literal[True]"
+        case True, False:
+            reveal_type(a)  # N: Revealed type is "Literal[True]"
+            reveal_type(b)  # N: Revealed type is "Literal[False]"
+        case False, _:
+            reveal_type(a)  # N: Revealed type is "Literal[False]"
+            reveal_type(b)  # N: Revealed type is "builtins.bool"
+        case _:
+            reveal_type(a)  # E: Statement is unreachable
+[builtins fixtures/tuple.pyi]
+
+[case testMatchExhaustiveTupleOfBoolsAndEnums]
+# flags: --enable-error-code exhaustive-match
+from enum import Enum
+from typing import Tuple
+
+class Color(Enum):
+    RED = 1
+    BLUE = 2
+
+def f1(a: bool, b: bool) -> float:
+    match a, b:
+        case True, True:
+            return 1
+        case True, False:
+            return 0.9
+        case False, True:
+            return 0.5
+        case False, False:
+            return 0
+
+def f2(t: Tuple[Color, Color]) -> int:
+    match t:
+        case (Color.RED, Color.RED):
+            return 1
+        case (Color.RED, Color.BLUE):
+            return 2
+        case (Color.BLUE, _):
+            return 3
+
+def f3(a: bool, b: bool) -> int:  # E: Missing return statement
+    match a, b:  # E: Match statement has unhandled case for values of type "tuple[Literal[False], Literal[False]]" \
+                 # N: If match statement is intended to be non-exhaustive, add `case _: pass`
+        case True, _:
+            return 1
+        case False, True:
+            return 2
+[builtins fixtures/tuple.pyi]
+
 [case testMatchSequenceWildcardRefutability]
 # flags: --strict-equality --warn-unreachable
 def f1(x: int | list[int]):